Case Report

Adult T-cell leukaemia/lymphoma in an adolescent patient: Expect the unexpected

Ibtisam Abdullah, Erica-Mari Nell, Zivanai C. Chapanduka
South African Journal of Oncology | Vol 4 | a121 | DOI: https://doi.org/10.4102/sajo.v4i0.121 | © 2020 Ibtisam Abdullah, Erica-Mari Nell, Zivanai C. Chapanduka | This work is licensed under CC Attribution 4.0
Submitted: 16 February 2020 | Published: 25 May 2020

About the author(s)

Ibtisam Abdullah, Division of Haematological Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Erica-Mari Nell, Division of Haematological Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Zivanai C. Chapanduka, Division of Haematological Pathology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa


Share this article

Bookmark and Share

Abstract

This case study explores a clinicopathological presentation of Adult T-cell leukaemia/lymphoma (ATLL) at Tygerberg Hospital; a disease associated with adulthood noted in an adolescent patient. Adult T-cell leukaemia–lymphoma oncogenesis develops through a multistep process with an accumulation of mutations. Infection through human T-lymphotropic virus type 1 (HTLV-1) is the first step of a multistep process resulting in eventual clonal proliferation of mature T-cells. There is a long latency period of 20–50 years from the time of infection with HTLV-1 to the development of symptoms of ATLL; thus, ATLL is a malignancy associated with adulthood. The median age of diagnosis is 58, ranging from the third to ninth decade of life. This is an ideal learning case as it highlights the importance of recognising ATLL in children and young adults in our population.

Keywords

ATLL; HTLV-1; T-cell lymphoproliferative neoplasm; flower cells; adolescent

Metrics

Total abstract views: 747
Total article views: 489


Crossref Citations

No related citations found.