Case Study

Double trouble: A case of synchronous presentation of acute myeloid leukaemia and multiple myeloma

Nomusa Mashigo
South African Journal of Oncology | Vol 4 | a147 | DOI: | © 2020 Nomusa Mashigo | This work is licensed under CC Attribution 4.0
Submitted: 30 July 2020 | Published: 26 October 2020

About the author(s)

Nomusa Mashigo, Department of Pathology, Division of Haematology, Faculty of Health Sciences, Stellenbosch University, Cape Town, South Africa


Malignancies following successful chemotherapy for various malignant diseases, including multiple myeloma (MM), are well known and documented. The occurrence of acute myeloid leukaemia (AML) after chemotherapy for MM with alkylating agents is well described; however, simultaneous occurrence of the two entities with no prior therapy is extremely rare. We describe a case of an elderly patient with no previous exposure to chemotherapy, who was diagnosed with both MM and AML concurrently. Very few similar cases have been described in the literature.


multiple myeloma; acute myeloid leukaemia; flame cells; synchronous; chemotherapy


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