Case Study

Low-dose localised electron radiotherapy in a case of refractory mycosis fungoides

George O. Joram, Henriette Burger, Willem I. Visser, Zainab Mohamed
South African Journal of Oncology | Vol 6 | a237 | DOI: https://doi.org/10.4102/sajo.v6i0.237 | © 2022 George O. Joram, Henriette Burger, Willem I. Visser, Zainab Mohamed | This work is licensed under CC Attribution 4.0
Submitted: 24 April 2022 | Published: 28 July 2022

About the author(s)

George O. Joram, Division of Radiation Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Henriette Burger, Division of Radiation Oncology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Willem I. Visser, Department of Medicine, Division of Dermatology, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa
Zainab Mohamed, Department of Radiation Oncology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa


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Abstract

We present a case of refractory mycosis fungoides (MF) that responded to low-dose localised electron radiotherapy. A 59-year-old man presented with a 5-year history of a generalised, pruritic, scaly, red skin rash that had recently become more nodular. Skin biopsy confirmed MF. After a variable initial response to topical steroids and oral methotrexate, progressive tumours were treated with low-dose electron radiotherapy. We describe the clinical effect of different radiation doses and fractionation schedules applied over a 2-year period. Our experience in this case of MF suggests that low-dose localised electron radiotherapy offers excellent palliation by effectively resolving tumorous lesions, improving quality of life and allowing for retreatment of refractory lesions.


Keywords

mycosis fungoides; electron radiotherapy; quality of life; cutaneous T-cell lymphoma; radiotherapy

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