Original Research

Adherence to guidelines on prophylaxis of chemotherapy-induced nausea and vomiting in the National Cancer Institute, Sudan

Moawia M.A. Elhassan, Arwa A.S.A. Ali, Mohamed O.M. Elmustafa
South African Journal of Oncology | Vol 1 | a9 | DOI: https://doi.org/10.4102/sajo.v1i0.9 | © 2017 Moawia M.A. Elhassan, Arwa A.S.A. Ali, Mohamed O.M. Elmustafa | This work is licensed under CC Attribution 4.0
Submitted: 12 January 2017 | Published: 28 February 2017

About the author(s)

Moawia M.A. Elhassan, National Cancer Institute, University of Gezira, Sudan
Arwa A.S.A. Ali, Wad Medani Teaching Hospital, Sudan
Mohamed O.M. Elmustafa, Faculty of Pharmacy, University of Gezira, Sudan

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Objective: To evaluate the adherence to American Society of Clinical Oncology (ASCO) guidelines for antiemetic prophylaxis of chemotherapy-induced nausea and vomiting and assess the outcomes of the prescribed antiemetic drugs.
Methods: This prospective, observational study enrolled chemotherapy-naive cancer patients who were admitted to the National Cancer Institute between May and July 2015 for intravenous chemotherapy. Patient’s demographic data, chemotherapy protocols and types of antiemetic drugs were collected by reviewing patients’ files, chemotherapy prescription forms and interviewing the patients.
Results: The data revealed that 90% of pre-chemotherapy antiemetic prescriptions did not adhere to antiemetic guidelines. The trends of non-adherence included an overuse of ondansetron (14%), under-prescribing of dexamethasone (16%) and corticosteroid duplication (14%). Regarding antiemetic use for the prevention of delayed emesis, the data showed that 90% of antiemetic prescriptions were non-adherent with ASCO guidelines, with overuse of ondansetron (20%) and metoclopramide (37%) and lack of dexamethasone prescriptions (80%) on days 2 and 3 being the most frequently reported trends. The percentage of patients with complete response (no emesis or rescue therapy) over 5 days post chemotherapy was 36%.
Conclusion: The study indicated an extremely low adherence rate to ASCO guidelines for antiemetic prophylaxis of chemotherapy-induced nausea and vomiting. Non-adherence included a trend of both underuse and overuse of indicated antiemetic medications.


antiemetics; ematogenicity; emesis; cancer


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Crossref Citations

1. Olanzapine for the Prevention of Chemotherapy-Induced Nausea and Vomiting: A Comparative Study From Sudan
Alaa A.M. Osman, Moawia M.A. Elhassan, Blala H.A. AbdElrahim, Fatima H.A. Ahmed, Jihad B.H. Yousif, Malak A.M. Ahmed, Romisa H.A. Abdelhafeez, Umsalama M.Y. Ahmed
Journal of Global Oncology  issue: 4  first page: 1  year: 2018  
doi: 10.1200/JGO.17.00216